WIMSA's regional office was set up in Windhoek , Namibia in order to co-ordinate efforts for San living across the entire southern African region. The WIMSA Team contains both San and non-San members of staff, although the organisation is governed by a Board consisting of San people from South Africa , Botswana and Namibia . WIMSA is also represented in Botswana by ‘WIMSA Botswana' which operates from a small office from D'kar, near Ghanzi.

For ten years WIMSA has worked closely with a variety of partners in relation to San human rights, cultural heritage and development. WIMSA's current partners include national and international governments, NGOs, UN agencies, researchers, the media and donors.

Most importantly, WIMSA has always sought to build up a strong grassroots membership amongst San communities themselves across southern Africa . These groups are often living in very remote areas with restricted access to modern communication infrastructures and this can present great logistical difficulties for both WIMSA employees and San communities. Despite this, many San frequently contact the regional WIMSA office in order to seek assistance with issues such as human rights abuses, political representation, development assistance, the protection of natural resources, aid relief, cultural practices and access to formal education.

WIMSA's Mission Statement: